Our Technology
Our core technology, known as Transcription Block Survival (TBS), screens peptides in a live cell system to select only those that ensure transcription factors are functionaly blocked, not simply bound.
Transcription blocked
Peptide library member does not bind target:
transcription is blocked and cells don't survive
Transcription blocked
Peptide library member binds target without functionally blocking:
transcription is blocked and cells don't survive
Cell Survival
Peptide library member functionally binds target:
transcription is possible and
cells survive
Peptide library members that functionally bind the target enable cell growth under competitive conditions. Using a series of growth competitions, the most active peptides are enriched and identified
Read more about the TBS platform and work that led to us to spin-out from the University of Bath here: