top of page

Our Technology

Our core technology, known as Transcription Block Survival (TBS), screens peptides in a live cell system to select only those that ensure transcription factors are functionaly blocked, not simply bound.

Peptide doesn't bind - small.png

Transcription blocked

Peptide library member does not bind target: 

transcription is blocked and cells don't survive

Peptide bind - small.png

Transcription blocked

Peptide library member binds target without functionally blocking:

transcription is blocked and cells don't survive

functional binder - small.png

Cell Survival

Peptide library member functionally binds target:

transcription is possible and

cells survive

Peptide library members that functionally bind the target enable cell growth under competitive conditions. Using a series of growth competitions, the most active peptides are enriched and identified

​

​

​​

​

​

​

Read more about the TBS platform and work that led to us to spin-out from the University of Bath here:

​

Brennan, A., Vance, K.W., and Mason J.M. Intracellular Cyclisation-Coupled Peptide Library Screening Yields Potent Transcription Factor Antagonists Cell Chem Biol 33, 409-23 (2026)


    Brennan, A., Tang T.M.S., and Mason J.M.. Enhancing the Efficacy, Utility, and Throughput of the Transcription Block Survival Peptide Library Screening Platform. JACS Au 5, 11, 5337-5345 (2025)

​​​

Brennan, A., Leech, J.T Kad, N.M., Mason, J.M. An Approach to Derive Functional Peptide Inhibitors of Transcription Factor Activity (2022), JACS Au, 2, 996-1006

​​

​

bottom of page